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Hello
i’m using Let’s Encrypt certification in my VPS(plesk) it seems everything ok an secure but in some big companies (i mean with secure internet server) they can not open the site .
You need to alter the configuration of your web server to exclude the blacklisted cipher(s) or ask someone who has configured that initially. It is well-known that enabling HTTP/2 requires following some rules in terms how ciphers have to be configured (I had a small post about that time ago).
what version of Firefox ??? One recent Firefox update started giving me SSL errors on all my sites. I went back to Firefox 51.0 and have not tested their latest version.
I think to get useful answers you need to do a bit more groundwork yourself.
A) What is the error message that they are getting?
B) What clients are they using (is it Internet Explorer x, Chrome Y etc)
C) Some big companies use older browsers as their standard browser so this could be the probelm
D) Are the failures consistent or intermediate
Once you narrow down what the actual problem is (what part of TLS is failing) you can take the appropriate steps to fix it or ask people for recommendations