It will listen on localhost 443 port and validate the domain in tls-alpn-01 method.
2. Support another ACME CA buypass.com
The www.buypass.com is another public trusted CA supporting ACME protocol.
[This is NOT a one-size-fits-all recommendation]
But, for those that have the ability to redirect inbound port 443 to any other port, the solution may even be simpler; in that, you could setup the ALPN listener on any unused port and then just update the router/firewall to connect external:443 to internal:ALPN port.
This may be especially useful/expeditious for those with very many virtual hosts:
All vhosts would remain on 443.
The router/firewall would direct all inbound 443 to the ALPN listener.
The ALPN listener would proxy to all 443 vhosts and handled ALPN auth requests (as needed).