Uff, good information, I did not know about the change of ACME and ZeroSSL, but for the moment I executed with the command --debug as it said in the error, and it worked!
The command you run:
/root/.acme.sh/acme.sh --issue -d enlacesystem.com.py -d www.enlacesystem.com.py --cert- file /etc/letsencrypt/live/enlacesystem.com.py/cert.pem --key-file /etc/letsencrypt/live/enlacesystem.com.py/privkey.pem --fullchain-file /etc/letsencrypt/live/enlacesystem.com.py/fullchain.pem -w /home/enlacesystem.com.py/public_html --debug
the result:
[mié jul 28 14:39:37 -04 2021] Success
[mié jul 28 14:39:56 -04 2021] Cert success.
[mié jul 28 14:39:56 -04 2021] Your cert is in /root/.acme.sh/enlacesystem.com.py/enlacesystem.com.py.cer
[mié jul 28 14:39:56 -04 2021] Your cert key is in /root/.acme.sh/enlacesystem.com.py/enlacesystem.com.py.key
[mié jul 28 14:39:56 -04 2021] The intermediate CA cert is in /root/.acme.sh/enlacesystem.com.py/ca.cer
[mié jul 28 14:39:56 -04 2021] And the full chain certs is there: /root/.acme.sh/enlacesystem.com.py/fullchain.cer
[mié jul 28 14:39:57 -04 2021] Installing cert to:/etc/letsencrypt/live/enlacesystem.com.py/cert.pem
[mié jul 28 14:39:57 -04 2021] Installing key to:/etc/letsencrypt/live/enlacesystem.com.py/privkey.pem
[mié jul 28 14:39:57 -04 2021] Installing full chain to:/etc/letsencrypt/live/enlacesystem.com.py/fullchain.pem
[mié jul 28 14:39:57 -04 2021] _on_issue_success
Thank you once for your help, you have guided me to solve it ...