I am using the Let’s Encrypt extension on Plesk Onyx.
I was able to easily create and install the cert for the primary domain, and Plesk was protected as well as https: to the domain. I installed the cert also for mail; however, that didn’t work – I got an error when attempting to connect to SMTP via Thunderbird. The error was hostname mismatch.
I found a solution and it is posted here:
This is a helpful site: https://ssl-tools.net