I believe the OCSP standard requires that OCSP queries be supported over HTTP and not HTTPS. I think it’s permitted, but not required by standards, to support OCSP queries over HTTPS. It appears that Let’s Encrypt simply does not support performing OCSP queries over HTTPS.
Akamai is the CDN that handles some parts of Let’s Encrypt’s infrastructure, including the OCSP responder.
I think the right thing to do in this situation is to ask akamai not to respond to https requests i.e. shutdown server on port 443. It’s the same as with LE IPv6/IPv4 preference, should one be assigned it must work.
If according to your statement OCSP is permitted over HTTPS then if enabled should work.