There are hundreds of clients. Certbot is the most popular - it was the first, developed in a partnership between EFF and ISRG, and aims to support the widest audience.
Different users have different needs.
Dehydrated is well respected and liked, and considered one of the major clients. However, it is not currently as actively developed like Certbot and some other clients are. This is most likely because it is stable and the maintainers consider it to be "feature complete" for now. There have not been many changes to the ACME process and LetsEncrypt implementation over the past few years - even 6 year old ACME v2 clients still work flawlessly.
The big changes that Certbot and other clients have been working on are:
- Certbot- supporting Apache/Nginx/etc
- All - new RFC specs, such as the ARI (Discontinuing support for ACME clients using draft-ietf-acme-ari-01 - #2 by beautifulentropy)
Other than that, the most popular clients tend to be well written, and well written clients typically support proper handling of alternate chains, async order finalization, updated error messages, etc.
TLDR: If you have expertise and knowledge with dehydrated within your network, it is an excellent option.
EDIT: typo. changed "actively" to "as actively"