See the topic below. WSGI needs special consideration when using the --apache plug-in.
The reason is that --apache plug-in will create a VirtualHost for HTTPS (port 443) based on what is seen in the VHost for port 80. This can cause duplication or errors in the WSGI config.
One work-around is to use the --webroot method instead and create your own VHost for HTTPS (port 443).
Or, as noted, check this topic for other WSGI changes that can help