How I can sign CSR Request Fro LetEncrypt
You don't usually do that manually with Let's Encrypt. The ACME Client used to get the cert takes care of that for you. That is true not only for Let's Encrypt but any other Certificate Authority that supports ACME.
A good place to start is: Getting Started - Let's Encrypt
Some ACME Clients allow you to create your own CSR. But, Let's Encrypt will only recognize certain parts of it. After reading Getting Started if you still think you need your own CSR please explain exactly what you hope to achieve and we can help.
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